See also this listing of medicines that include codeine and browse The customer information and facts drugs (CMI) leaflet to the model prescribed, or:

Breastfeeding. Never just take promethazine/phenylephrine/codeine if you are breastfeeding. Promethazine/phenylephrine/codeine can go into breast milk. Inform your healthcare provider If you're breastfeeding or plan to breastfeed.

As soon as codeine enters your process, your body breaks it down and converts it into morphine. Codeine is classed for a depressant, meaning it slows down your nervous system, which include your respiration rate.

These signs or symptoms may perhaps reveal that you're an "extremely-immediate metabolizer of codeine". Consequently, there might be an excessive amount morphine in the body plus much more Unwanted effects from morphine than regular. Young children may be Primarily sensitive to this impact. Don't give this medication to:

22 A urine sample confirmed enhanced metabolite concentrations. Genotyping of CYP2D6 was carried out, and three functional alleles were discovered that were in keeping with extremely-quick metabolism.

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Constantly go through the label on prescription bottles to find out if a drugs is made up of codeine or tramadol, or talk to your son or daughter’s wellbeing treatment provider or maybe a pharmacist.

Bone Marrow Suppression. Promethazine/phenylephrine/codeine may cause your bone marrow to not make enough cells. This can result in minimal blood levels of significant cells, such as pink blood cells, white blood cells, platelets, and neutrophils.

Bronchial asthma As well as other Respiratory Disorders: Narcotic analgesics or cough suppressants, which include codeine, shouldn't be used in asthmatic sufferers (see CONTRAINDICATIONS). Nor should they be Utilized in acute febrile health here issues connected with productive cough or in chronic respiratory disease exactly where interference with capability to very clear the tracheobronchial tree of secretions would have a deleterious impact on the affected individual’s respiratory purpose. Hypotensive Effect: Codeine may perhaps deliver orthostatic hypotension in ambulatory people.

Promethazine should be utilised cautiously in persons with cardiovascular disease or with impairment of liver perform.

If a nursing mother can be an ultra-quick metabolizer of codeine, it could lead on to morphine overdose from the nursing child and lead to extremely really serious Negative effects.

潜在的に深刻な副作用は他のオピオイドと同様に呼吸抑制である。この抑制は用量依存であり、この呼吸抑制が過量服用時に深刻な結果をもたらす。

Pregnancy. Promethazine/phenylephrine/codeine may perhaps result in damage to an unborn infant. Inform your Health care supplier If you're or plan to become pregnant. Your healthcare supplier will advise you if you must choose promethazine/phenylephrine/codeine when you are pregnant or trying to get pregnant.

Promethazine and codeine needs to be used through pregnancy only if the probable benefit justifies the probable threat to the fetus.